Dr. Sophie Laye





Academic Degree(s)

Ph.D., HDR





Current Position

  • Research Director INRA
  • Director of NutriNeuro Institute


Professional Experience

  • Research Director at INRA 2003-actual
  • Director of NutriNeuro Institute 2009-actual
  • Director of the international Lab OptiNutriBrain (Laval Univ-Bordaeu Univ) 2014-actual


Education & Training

  • Post-Doc in Neurochemistry 1995-1997
  • PhD in Neurosciences 1992-1995
  • Master in Neuroscience 1990-1992



  • Fondation pour la Recherche Médicale Award (équipe FRM)
  • Fondation de France Award
  • Scientific Breakthrough Award, Lauriers de l’INRA
  • Biotechnology Investigator Award (EU)
  • IPSEN Investigator Award (Neuroimmunoendocrinology)


Research Grants

  • ANR MoodFood
  • FRM
  • Fondation de France
  • Région Aquitaine Neuronalg


Committee & Membership

  • Scientific council Bordeaux University
  • Société Française de Nutrition
  • Cross appointment Dpt of Nutrition University of Toronto, Canada


Selected Publication

114 articles and reviews, 14 book chapters

  • Lafourcade M, Larrieu, T., Mato S, Duffaud A, Sepers M, Matias I, De Smedt V, Labrousse V, Bretillon L, Matute C, Rodríguez-Puertas R, Layé S # and Manzoni O# (#, equal contribution), Nutritional Omega-3 deficiency abolishes endocannabinoid mediated neuronal functions, Nature Neuroscience, 2011, 14(3):345-50.
  • Larrieu, T., Hilal, M., de Smedt-Peyrusse, V., Sans, N., Capuron, L., Layé. S. Hypothalamo-pituitary-adrenal axis mediates n-3 polyunsaturated fatty acids deficient-diet induced depressive- and anxiety-like symptoms along with neuronal atrophy, Translational Psychiatry, 2014, 4:e437-
  • Delpech JC, Madore C, Joffre C, Aubert A, Kang JX, Nadjar A and Layé S, Transgenic increase in n-3/n-6 Fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation, Neuropsychopharmacology, 2015, 40(3):525-36.
  • Bazinet R and Layé S., Polyunsaturated fatty acids and their metabolites in brain function and disease, Nature Reviews Neuroscience, 2014, 15(12):771-85
  • Delpech JC, Thomazeau A, Madore C, Bosch-Bouju C, Larrieu T, Lacabanne C, Remus-Borel J, Aubert A, Joffre C, Nadjar A*, Layé S*, Dietary n-3 PUFAs deficiency increases vulnerability to inflammation-induced spatial memory impairment, Neuropsychopharmacology, 2015, 40(12):2774-87
  • Thomazeau A#, Bosch-Bouju C#, Manzoni O and Layé S, Nutritional n-3 PUFA deficiency abolishes endocannabinoid gating of hippocampal long-term potentiation, Cerebral Cortex, 2016 Mar 5. pii: bhw052
  • Rey C, Nadjar A, Buaud B, Vaysse C, Aubert A, Pallet V, Layé S, Joffre C. Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro. Brain Behav Immun. 2016 Jul;55:249-59.
  • Bosch-Bouju C, Larrieu T, Manzoni O and Layé S, Endocannabinoid Hebbian synaptic plasticity in the nucleus accumbens is a marker of susceptibility to social defeat stress, Cell Reports, 2016, 16(5):1237-42
  • Layé S, Nadjar A, Joffre C and Bazinet RP, Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology, Pharmacological Reviews, 2018 Jan;70(1):12-38
  • Labrousse VF, Lyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C, Nadjar A* and Layé S*, Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation, Brain Behavior and Immunity, 2018 Jun 4. pii: S0889-1591(18)30220-4.