Prof. Atsuyoshi Shimada


Academic Degree(s)





Current Position

  • Professor of Pathology, Kyorin University Faculty of Health Sciences


Professional Experience

  • Assistant Professor, Department of Pathology, Atomic Bomb Disease Institute, Nagasaki University (1998 Jan-1998 Jun)
  • Laboratory Director, Laboratory of Neuropathology, Institute for Developmental Research, Aichi Human Service Center (1998 Jul-2016 Jul)
  • Department Head, Department of Pathology and Laboratory Medicine, Central Hospital, Aichi Human Service Center (2012 Apr-2017 Mar)


Education & Training

  • ​Kyoto University Faculty of Medicine and Graduate School of Medicine (Kyoto, Japan)(1982 Apr-1993 Mar)
  • Visiting Fellow, Gerontology Research Center, National Institute on Aging, National Institutes of Health (Baltimore, USA) (1993 Jun-1995 Jun)
  • Postdoctoral Residency Fellow of Pathology, Columbia University College of Physicians & Surgeons (New York, USA) (1995 Jul-1997 Dec)




  • Best Poster Award (Jun 15, 2009 from Japan Geriatrics Society)
  • Marquis Who's Who in the World, 2004-2017
  • Marquis Who's Who Lifetime Achievement Award, 2017


Research Grants


  • Research Project Number: 18590396 Title: Genetic analysis of spontaneous animal model of neurodegeneration to study molecular mechanisms underlying selective regional vulnerability, Fiscal Year: 2006-2008, Amount of direct costs: 3,500,000 Yen
  • Research Project Number: 21590458 Title: Induction of neuroprotective microenvironment and intervention of neurodegenerative condition by the intra-bone marrow bone-marrow transplantation, Fiscal Year: 2009-2011, Amount of direct costs: 3,600,000 Yen
  • Research Project Number: 24650190, Title: Meningeal immunity as a novel target for treating neurodevelopmental disorders induced by maternal immune activation, Fiscal Year: 2012-2013, Amount of direct costs: 3,000,000 Yen
  • Research Project Number: 25290020, Title: Tissue constructions and functions of the immunity stationed in the meninges and choroid plexus, Fiscal Year: 2013-2017, Amount of direct costs: 13,100,000 Yen
  • Research Project Number: 18K07072, Title: Dynamics of bone marrow-derived immune cells migrating to the brain via the choroid plexus, Fiscal Year: 2018-2021, Amount of direct costs: 3,400,000 Yen


Committee & Membership

  • Japanese Society of Pathology (1988-present; Councilor, 2000-present)
  • Japanese Society of Neuropathology (1991-present; Councilor, 2004-present)
  • Psychoneuroimmunlogy Research Society (PNIRS) (2010-present)
  • PNIRS Asia-Pacific Committee Member (2017-present)


Selected Publication


Original Articles  (*Corresponding author)

  • Shimada A, Ohta A, Akiguchi I and *Takeda T : Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. Journal of Neuropathology and Experimental Neurology 51: 440-450, 1992
  • Shimada A, Mason CA and *Morrison ME : TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells. Journal of Neuroscience 18: 8559-8570, 1998
  • *Shimada A, Keino H, Satoh M, Kishikawa M, Seriu N and Hosokawa M : Age-related progressive neuronal DNA damage associated with cerebral degeneration in a mouse model of accelerated senescence. Journals of Gerontology Series A: Biologic Sciences and Medical Sciences 57: B415-421, 2002
  • *Shimada A, Tsuzuki M, Keino H, Satoh M, Chiba Y, Saitoh Y and Hosokawa M : Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration. Neuropathology and Applied Neurobiology 32: 1-14, 2006
  • *Shimada A, Keino H, Kawamura N, Chiba Y and Hosokawa M : Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: A model of cerebral degeneration. Neuropathology and Applied Neurobiology 34: 33-51, 2008
  • Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M and *Shimada A : Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain, Behavior, and Immunity 25: 83-100, 2011
  • Hasegawa-Ishii S, *Shimada A, Inaba M, Li M, Shi M, Kawamura N, Takei S, Chiba Y, Hosokawa M and Ikehara S : Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus. Brain, Behavior, and Immunity 29: 82-97, 2013
  • Hasegawa-Ishii S, Inaba M, Li M, Shi M, Umegaki H, Ikehara S and *Shimada A : Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. Brain Structure and Function (ePub in Jan, 2015; doi 10.1007/s00429-014-0987-2) 221:1513-1531, 2016
  • Hasegawa-Ishii S, Inaba M, Umegaki H, Unno K, Wakabayashi K and *Shimada A : Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain–immune interface. Scientific Reports 6:25457, 2016 (DOI: 10.1038/srep25457)


Review Articles (*Corresponding author)

  • *Shimada A and Hasegawa-Ishii S : Histological architecture underlying brain–immune cell–cell interactions and the cerebral response to systemic inflammation. Frontiers in Immunology Vol. 8, Article 17, 2017 (DOI: 10.3389/fimmu.2017.00017)