Prof. Po-See Chen




Academic Degree(s)

M.D., PhD




Current Position

  • Chairperson and Professor

  • Visiting Staff Psychiatrist, Department of Psychiatry

    Professor (joint appointment), Institute of Behavioural Medicine College of Medicine and Hospital 

    National Cheng Kung University, Tainan, Taiwan


Professional Experience

  • Visiting Research Fellow, Neuropharmacology Laboratory, NIEHS/NIH, USA
  • Research scholar, Duke University Medical Center, Department of Psychiatry and Behavioral Sciences. N.C., USA
  • Visiting Staff Psychiatrist, Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan


Research Grants

  • The role of chronic social stress in the comorbidity of mood disorders and metabolic syndrome
  • To explore the profile of bipolar II disorder from genetics, immunological markers and cognitive aspects
  • Using the valproate-induced autistic spectrum disorder rat model to study the effect of emotional brain neuroinflammation on social emotional behaviour
  • Dopaminergic modulation of mind: impact of sub-receptor and dosage on different stage of motor learning
  • Role of inflammation factors and insulin resistance in the pathophysiology and treatment response of major depressive disorder – a translational study


Committee & Membership

  • Committee, Taiwan International Graduate Program-The Interdisciplinary Neuroscience graduate program (Academia Sinica-NCKU) and TIGP-International Internship Program (IIP)
  • The Taiwanese Society of Schizophrenia Research
  • Collegium Internationale Neuro-Psychopharmacologicum


Selected Publication

  • Chen YW, Lin HC, Ng MC, Hsiao YH, Wang CC, Gean PW*, Chen PS*: Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Frontiers in Behavioral Neuroscience 2014 Jun;8:219  (SCI)
  • Chang WH, Lee IH, Chen KC, Chi MH, Chiu NT, Yao WJ, Lu RB, Yang YK, Chen PS*: Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits — a SPECT study. Psychoneuroendocrinology 2014 Sep;47:212-20 (SCI)
  • Chang HH, Chou C-H, Yang YK, Lee IH, Chen PS*: Association between ABCB1 Polymorphisms and Antidepressant Treatment Response in Taiwanese Major Depressive Patients. Clinical Psychopharmacology and Neuroscience 2015 Dec;13(3):250-5 (SCI)
  • Ma DY, Chang WH, Chi MH, Tsai HC, Yang YK, Chen PS*: The correlation between perceived social support, cortisol and brain derived neurotrophic factor levels in healthy women. Psychiatry Research 2016 May 30;239:149-53 (SCI&SSCI)
  • Chang HH, Wang T-Y, Lee IH, Lee S-Y, Chen KC, Huang S-Y, Yang YK, Lu R-B, Chen PS*: C-reactive protein: a differential biomarker for major depressive disorder and bipolar II disorder. World Journal of Biological Psychiatry 2017 Feb;18(1):63-70 (SCI)
  • Kuo MF, Chen PS, Nitsche MA*: The application of tDCS for the treatment of psychiatric diseases. International Review of Psychiatry. 2017 Apr;29(2):146-67 (SSCI)
  • Chang HH, Chen PS*, Wang TY, Lee SY, Chen SL, Huang SY, Hong JS, Yang YK, Lu R-B: Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder. Journal of Affective Disorders 2017 Jun 9;221:151-57  (SCI&SSCI)
  • Lien Y-J, Chang HH, Tsai H-C, Yang YK, Lu R-B, Chen PS*: Plasma oxytocin levels in major depressive and bipolar II disorders. Psychiatry Research 2017 Dec;258:402-6 (SCI&SSCI)
  • Chang HH*, Chen PS, Cheng YW, Wang T-Y, Yang YK, Lu R-B: FGF21 is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate. International Journal of Neuropsychopharmacology 2018 Apr 1;21(4):319-24 (SCI)
  • Wu HF, Chen PS, Hsu YT, Lee CW, Wang TF, Chen YJ, Lin H-C*: D-Cycloserine Ameliorates Autism-like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model. Molecular Neurobiology 2018 Jun;55(6):4811-24 (SCI)