Dr. Floyd Chilton

Academic Degree(s)






Current Position

  • Professor of Physiology/Pharmacology and Cancer Biology, Wake Forest School of Medicine


Professional Experience

  • Director of the NCCAM/ODS-sponsored Center for Botanical Lipids and Inflammatory Disease Prevention, 2005-2016
  • Author of five bestselling books focused on nutrition, diet, and physical and mental health including Inflammation Nation (Simon and Schuster), Win the War Within (Rodale), The Gene Smart Diet (Rodale), Made to Crave Action Plan (Zondervan) and The Rewired Brain, 2005-2016


Education & Training

  • B.S. Biology and Chemistry, Western Carolina University, 1977-1980
  • Ph.D. in Biochemistry, Wake Forest University, 1980-1984
  • Postdoctoral Fellow in the Department of Pharmacology, University of Colorado, 1984-1986



  • Alumni Achievement Award at Western Carolina University
  • Ernst and Young Entrepreneur of the Year Finalist Award for the Carolinas
  • Denham Harmon Outstanding Research Achievement Award from the American College for Advancement of Medicine,
  • Established Investigator of the Year Award at Wake Forest School of Medicine in 2016


Research Grants

  • R01 AT008621 (PI, Chilton), Role of PUFA-Gene Interactions in Health Disparities
  • Wake Forest Comprehensive Cancer Center Program Project Award (PI, Chilton), Precision Nutrition and Cancer: Impact of Diet-Gene Interactions on Polyunsaturated Fatty Acid Metabolism, Prostate Cancer Risk and Prostate Cancer Disparities

  • K25HL133611-01A1 (Co-investigator, Chilton), An Integrated Investigation of the Interaction between PUFAs and Genetic Variants in Trauma and Critical Care


Committee & Membership

  • Board of Visitors, Western Carolina University

  • Chairman of the Board, The Persecution Project

  • ASBMB Today Advisory Committee


Selected Publication

  • Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant S, Barnes  KC, Chilton FH. Association of fatty acid desaturase (FADS) gene cluster genetic variants with omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. J Lipid Res. Sept;51(9):2766-74, 2010.
  • Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively SA. Depression and altered serum lipids in cynomolgus monkeys on a Western diet. Physiol Behav.104: 222-27, 2011.
  • Mathias RA, Hugenschmidt  CE, Sergeant S, Torgerson DG, Ziegler JT, Ivester P, Case LD, Yanek LR, Bowden DW, Freedman BI, Rudock ME, Becker LC, Langefeld CD, Becker DM, Barnes KC, Chilton FH. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genetics.  May 20; 12(1):50, 2011.
  • Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, ¬¬-Ainsworth, HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) in African Americans and European Americans with diabetes/metabolic syndrome. Brit J Nutr 107:547, 2012.
  • Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DJ, Ruczinski I, Sergeant S, Barnes KC, Chilton FH. Adaptive evolution of the FADS gene cluster within Africa. PLoS ONE Sept 19; 7(9): e44926, 2012.
  • Mathias RA, Seeds MC, Pani V, Sergeant S, Chilton FH. Genetic variants in the FADS gene:  implications for dietary recommendations for fatty acid intake. Curr Nutr Rep Jun;3(2):139-148, 2014.
  • Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC and Mathias RA. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients. 6(5):1993-2022, 2014
  • Hester GA, Murphy, RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton, FH. Relationship between common variants in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. J Biol Chem, Jun 24. pii: jbc.M114.579557, 2014.
  • Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC,  Rahbar E, Morgan TM,  Welborn  A, Chilton SM, Gillis J, Hester A, Rukstalis M, and Sergeant S,  Chilton FH. Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav 156:71-78, 2016
  • Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, and Seeds MC. Precision Nutrition and omega-3 polyunsaturated fatty acids: a case for personalized supplementation approaches for the prevention and management of human diseases. Nutrients Oct 25;9(11). pii: E1165. doi: 10.3390/nu9111165, 2017.