Prof. Makoto Arita

Academic Degree(s)

Ph. D




Current Position

  • Team leader, Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan
  • Professor, Division of physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan


Professional Experience

  • 1997-2000, Assistant Professor, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
  • 2003-2006, Instructor, Brigham&Women’s Hospital/Harvard Medical School, Boston, USA
  • 2007-2014, Associate Professor, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan


Education & Training

  • 1994-1997, Ph.D. Student, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
  • 2000-2003, Postdoctoral Fellow, Brigham&Women’s Hospital/Harvard Medical School, Boston, USA



  • 2016, Lands Science Award, Japan Society for Lipid Nutrition
  • 2009, Young Scientists’ Prize, Ministry of Education, Culture, Sports, Science and Technology, Japan
  • 2005, Young Investigator Award, 9th International Conference of  Eicosanoids other Bioactive Lipids in Cancer, Inflammation & Related Diseases (San Francisco)


Research Grants

  • Grant-in-aid for Scientific Research in Innovative Areas “Lipoquality” (#15H05897, 15H05898)
  • Grant-in-aid for Scientific Research (B)(# 15H04648)
  • Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry


Committee & Membership

  • Vice President, International Society for Omega-3 Research
  • Director, Japan Society for Biomedical Mass Spectrometry
  • Councilor, Japan Society for Lipid Nutrition


Selected Publication

  • *Kunisawa J, *Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut. Sci Rep 5, 9750 (2015)
  • Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, *Arita M. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. J Exp Med 211, 1673-1687 (2014)
  • Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, *Arita M. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J 28, 4036-4043 (2014)
  • Kubota T, *Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H. Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxy eicosatetraenoic acid. FASEB J 28, 586-593 (2014)
  • Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanabe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, *Imai Y. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell 153, 112-125 (2013)
  • Isobe Y, *Arita M, Matsueda S, Iwamoto R, Fujihara T, Nakanishi H, Taguchi R, Masuda K, Sasaki K, Urabe D, Inoue M, Arai H. Identification and structure determination of novel anti-inflammatory mediator resolvin E3: 17,18-dihydroxyeicosapentaenoic acid. J Biol Chem 287, 10525-10534 (2012)
  • Yamada T, Tani Y, Nakanishi H, Taguchi R, *Arita M, Arai H. Eosinophils promote resolution of acute peritonitis by producing pro-resolving mediators in mice. FASEB J 25 561-568 (2011)
  • Schwab JM, Chiang N, Arita M, *Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447, 869-874 (2007)
  • Arita M, Yoshida M, Hong S, Tjonahen E, Glickman J, Petasis NA, Blumberg RS, *Serhan CN. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci USA 102, 7671-7676 (2005)
  • Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, *Serhan CN. Stereochemical assignment, anti-inflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 201, 713-722 (2005)