Team leader, Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan
Professor, Division of physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan
Professional Experience
1997-2000 Assistant Professor, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
2003-2006 Instructor, Brigham&Women’s Hospital/Harvard Medical School, Boston, USA
2007-2014 Associate Professor, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
Education & Training
1994-1997 Ph.D. Student, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
2000-2003 Postdoctoral Fellow, Brigham&Women’s Hospital/Harvard Medical School, Boston, USA
Awards
2016 Lands Science Award, Japan Society for Lipid Nutrition
2009 Young Scientists’ Prize, Ministry of Education, Culture, Sports, Science and Technology, Japan
2005 Young Investigator Award, 9th International Conference of Eicosanoids other Bioactive Lipids in Cancer, Inflammation & Related Diseases (San Francisco)
Research Grants
Grant-in-aid for Scientific Research in Innovative Areas “Lipoquality” (#15H05897, 15H05898)
Grant-in-aid for Scientific Research (B)(# 15H04648)
Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry
Committee & Membership
Vice President, International Society for Omega-3 Research
Director, Japan Society for Biomedical Mass Spectrometry
Councilor, Japan Society for Lipid Nutrition
Selected Publication
Isobe Y, Itagaki M, Ito Y, Naoe S, Kojima K, Ikeguchi M, *Arita M. Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid. Sci Rep 8, 7954 (2018)
Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, *Osumi N. Maternal dietary balance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites. Stem Cells 34, 470-482 (2016)
*Kunisawa J, *Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut. Sci Rep 5, 9750 (2015)
Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, *Arita M. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. J Exp Med 211, 1673-1687 (2014)
Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, *Arita M. Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. FASEB J 28, 4036-4043 (2014)
Kubota T, *Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H. Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid. FASEB J 28, 586-593 (2014)
Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanabe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, *Imai Y. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell 153, 112-125 (2013)
Isobe Y, *Arita M, Matsueda S, Iwamoto R, Fujihara T, Nakanishi H, Taguchi R, Masuda K, Sasaki K, Urabe D, Inoue M, Arai H. Identification and structure determination of novel anti-inflammatory mediator resolvin E3: 17,18-dihydroxyeicosapentaenoic acid. J Biol Chem 287, 10525-10534 (2012)
Yamada T, Tani Y, Nakanishi H, Taguchi R, *Arita M, Arai H. Eosinophils promote resolution of acute peritonitis by producing pro-resolving mediators in mice. FASEB J 25 561-568 (2011)
Schwab JM, Chiang N, Arita M, *Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes.Nature 447, 869-874 (2007)
