Prof. Makoto Arita email@example.com
Omega-3 polyunsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are widely held to have beneficial effects in many inflammatory diseases. Also, elevation in tissue levels of omega-3 PUFAs in fatty acid n-3 desaturase (fat-1) transgenic mice exhibits resistance to inflammatory disease models. To elucidate the molecular mechanisms underlying the beneficial effects of omega-3 PUFAs, we developed a comprehensive LC-MS/MS-based lipidomic system that can detect and quantify more than 500 of fatty acid metabolites simultaneously. Using a genetic model, namely fat-1 transgenic mice, we examined the biological impact and lipid metabolome changes with enhanced omega-3/omega-6 fatty acid ratio at tissue and cellular levels. Also we demonstrated LC-MS/MS-based lipidomic analyses, and identified several unique omega-3 fatty acid metabolites with potent biological activities in vivo. These metabolites may underlie some of the beneficial actions of omega-3 PUFAs in controlling inflammation and related diseases.
Taiwanese Society for Nutritional Psychiatry Research 台灣營養精神醫學研究學會 firstname.lastname@example.org
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